Interleukin-10 inhibits spontaneous sleep in rabbits.
J Interferon Cytokine Res
; 19(9): 1025-30, 1999 Sep.
Article
em En
| MEDLINE
| ID: mdl-10505745
ABSTRACT
Proinflammatory cytokines, including interleukin-1beta(IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) are involved in sleep regulation. IL-10 is an anti-inflammatory cytokine that inhibits proinflammatory cytokine production. We hypothesized that IL-10 could attenuate sleep. Thirty-one male rabbits were used. Three doses of IL-10 (5 ng, 50 ng, and 250 ng) were injected intracerebroventricularly during the rest (light) period. One dose of IL-10 (250 ng) was injected during the active (dark) cycle. Appropriate time-matched control injections of saline were given to the same rabbits on different days. The two highest doses of IL-10 significantly inhibited spontaneous nonrapid eye movement sleep if IL-10 was given during the light cycle. The highest dose of IL-10 (250 ng) also significantly decreased rapid eye movement sleep. IL-10 administered at dark onset had no effect on sleep. The sleep inhibitory properties of IL-10 provide additional evidence for the hypothesis that a brain cytokine network is involved in regulation of physiologic sleep.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sono
/
Interleucina-10
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article