[Isolated increased aPTT with anamnestic hemorrhagic diathesis--severe FXI deficiency]. / Isoliert verlängerte aPTT mit anamnestischer hämorrhagischer Diathese--Schwerer FXI-Mangel.
Ther Umsch
; 56(9): 502-4, 1999 Sep.
Article
em De
| MEDLINE
| ID: mdl-10517119
ABSTRACT
A 47-year-old patient with several episodes of bleeding after tonsillectomy, after an excision of a sacral dermoid and after urinary tract surgery presented with a mechanical ileus and was admitted to the department of visceral surgery. Preoperative analysis revealed a prolonged activated partial thromboplastin time (aPTT) of 93 seconds (normal range 40-60 seconds), whereas the prothrombin time and thrombin time were normal. A mixture of 1 volume patient plasma and 1 volume normal plasma gave a normal aPTT, both before and after incubation of the plasma mixture at 37 degrees C for 1 hour. The patient's history and the prolonged aPTT as the only abnormal clotting test indicated deficiency of either factor VIII, factor IX, factor XI or von Willebrand factor with consecutively diminished factor VIII. Laboratory analysis revealed a factor XI of 4% indicating severe factor XI deficiency. Laparotomy was successfully performed without any hemorrhagic complications under fresh frozen plasma substitution.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tempo de Tromboplastina Parcial
/
Hemorragia Pós-Operatória
/
Deficiência do Fator XI
/
Transtornos Hemorrágicos
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
De
Ano de publicação:
1999
Tipo de documento:
Article