Cloning, genomic organization and expression of a putative human transmembrane protein related to the Caenorhabditis elegans M01F1.4 gene.
Gene
; 240(1): 67-73, 1999 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-10564813
ABSTRACT
A novel human transcript CG-2 (C9ORF5), was isolated from the familial dysautonomia candidate region on 9q31 using a combination of cDNA selection and exon trapping. CG-2 was detected as a relatively abundant 8kb transcript in all adult and fetal tissues with the exception of adult thymus. Genomic analysis of CG-2 identified 18 exons that span more than 110kb. The gene encodes a 911-amino-acid protein with a predicted molecular weight of 101kDa and a hypothetical pI of 9.03. Sequence analysis of CG-2 indicates that it is likely to encode a transmembrane protein. Here, we assess CG-2 as a candidate for familial dysautonomia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Genes de Helmintos
/
Genes
/
Proteínas de Membrana
Limite:
Adult
/
Animals
/
Humans
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article