Contribution of the MexAB-OprM multidrug efflux system to the beta-lactam resistance of penicillin-binding protein and beta-lactamase-derepressed mutants of Pseudomonas aeruginosa.
J Antimicrob Chemother
; 44(4): 537-40, 1999 Oct.
Article
em En
| MEDLINE
| ID: mdl-10588316
ABSTRACT
Deletion of the mexAB-oprM multidrug efflux operon substantially compromised the beta-lactam resistance of beta-lactamase-derepressed mutants of Pseudomonas aeruginosa, although it had only a modest impact on resistance of a penicillin-binding protein mutant. This highlights the multifactorial nature of beta-lactam resistance in this organism. Moreover, the contribution of efflux to the net resistance seen in some beta-lactam-resistant mutants suggests that inhibition of MexAB-OprM-mediated drug efflux might be an effective approach to overcoming beta-lactam resistance attributed to efflux as well as to other mechanisms of beta-lactam resistance.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Óperon
/
Pseudomonas aeruginosa
/
Proteínas de Bactérias
/
Beta-Lactamases
/
Muramilpentapeptídeo Carboxipeptidase
/
Proteínas de Transporte
/
Peptidil Transferases
/
Hexosiltransferases
/
Antibacterianos
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article