Synthesis of all possible regioisomers of scyllo-inositol phosphate.
Bioorg Med Chem
; 7(11): 2577-89, 1999 Nov.
Article
em En
| MEDLINE
| ID: mdl-10632068
ABSTRACT
scyllo-Inositol is the all equatorial stereoisomer of myo-inositol. All possible 12 regioisomers of scyllo-inositol phosphate were synthesized for the first time via a scyllo-inositol benzoate intermediate, which was derived from a myo-inositol derivative. The stereoinversion of myo-inositol into scyllo-inositol was accomplished by Mitsunobu reaction of the vicinal cis-diol. The requisite intermediates, scyllo-inositol benzoates were obtained by benzoyl migration or random benzoylation, and phosphorylated to give scyllo-IPn.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfatos de Inositol
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article