Isolation and structure elucidation of new cytotoxic steroids from the gorgonian Leptogorgia sarmentosa.
Steroids
; 65(2): 85-8, 2000 Feb.
Article
em En
| MEDLINE
| ID: mdl-10639019
ABSTRACT
The gorgonian Leptogorgia sarmentosa contains three new steroids, (20S)-20-hydroxycholestane-3,16-dione (1), (16S, 20S)-16,20-dihydroxycholestan-3-one (2), and (20S)-20-hydroxycholest-1-ene-3,16-dione (3) together with a known related compound (4). Their structures were defined by spectroscopic analysis. The new steroids exhibited significant cytotoxicity against four tumor cell lines (ED50 = 1 microg/ml).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esteroides
/
Colestanonas
/
Cnidários
/
Citotoxinas
Limite:
Animals
/
Humans
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article