Distribution of the receptor EphA7 and its ligands in development of the mouse nervous system.
Brain Res Mol Brain Res
; 74(1-2): 225-30, 1999 Dec 10.
Article
em En
| MEDLINE
| ID: mdl-10640695
ABSTRACT
EphA7 is a receptor tyrosine kinase of the Eph family. We have mapped EphA7 immunoreactivity and ligand binding in mouse embryo heads and developing brain. Immunoreactivity for the full-length receptor is found in all the cell populations that express EphA7 mRNA. In particular, it is located on growing axons from EphA7-expressing neurons, both in the trigeminal nerve and in developing brain. In many cases it persists in terminal fields in adult brain. Ligand is detected in a largely complementary distribution in embryos, but is surprisingly weak or undetectable in the target regions of many EphA7-positive axons postnatally.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Proteína Tirosina Quinases
/
Sistema Nervoso
Limite:
Animals
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article