Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism.
Nat Med
; 6(2): 151-8, 2000 Feb.
Article
em En
| MEDLINE
| ID: mdl-10655102
ABSTRACT
Trypsin and mast cell tryptase cleave proteinase-activated receptor 2 and, by unknown mechanisms, induce widespread inflammation. We found that a large proportion of primary spinal afferent neurons, which express proteinase-activated receptor 2, also contain the proinflammatory neuropeptides calcitonin gene-related peptide and substance P. Trypsin and tryptase directly signal to neurons to stimulate release of these neuropeptides, which mediate inflammatory edema induced by agonists of proteinase-activated receptor 2. This new mechanism of protease-induced neurogenic inflammation may contribute to the proinflammatory effects of mast cells in human disease. Thus, tryptase inhibitors and antagonists of proteinase-activated receptor 2 may be useful anti-inflammatory agents.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Trombina
/
Inflamação
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article