Thirty-four patients with carcinoma of the cervical esophagus treated with chemoradiation therapy.
Arch Otolaryngol Head Neck Surg
; 126(2): 205-8, 2000 Feb.
Article
em En
| MEDLINE
| ID: mdl-10680872
ABSTRACT
OBJECTIVE:
To review the experience of 2 institutions in the management of localized carcinoma of the cervical esophagus with chemoradiation therapy.DESIGN:
A series of 34 patients received chemoradiation therapy for a 5-year period. All patients were treated with curative intent. Three different regimens were used, all involving concomitant chemotherapy and high-dose radiation therapy. Data relating to toxic effects, local control of disease, and disease-free and overall survival were prospectively collected.SETTING:
Two combined clinics at separate major hospitals where multidisciplinary care is the standard practice for this disease. PATIENTS Patients with biopsy-proved carcinoma of the cervical esophagus.INTERVENTIONS:
Patients received 3 different chemotherapy regimens. Two of the regimens used a combination of cisplatin and fluorouracil. The high-dose cisplatin regimen was a large dose of cisplatin (80 mg/m2) given on days 1 and 22 followed by a 96-hour infusion of fluorouracil (800 mg/m2) from days 2 to 5 and from days 23 to 26. The low-dose cisplatin regimen was cisplatin, 20 mg/m2, from days 1 to 5 and from days 22 to 26 and the same 96-hour infusion of fluorouracil. The third regimen used fluorouracil alone. The mean radiation dose administered was 61.2 Gy in 29.6 fractions during 41.8 days using 4- or 6-mV photons and a shrinking field technique.RESULTS:
The results of treatment have shown a high rate of local control, although some patients developed metastases. The local complete response rate following treatment was 91%, and the rate of local control of disease was 88%. The projected actuarial 5-year survival rate was 55%. Death from other causes was common. The acute toxic effects of the treatment were acceptable, with only 5 patients requiring nasogastric feeding or gavage. Two patients died of complications related to strictures.CONCLUSION:
Concomitant chemoradiation therapy, should be the treatment of choice for carcinoma of the cervical esophagus.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Esofágicas
/
Carcinoma de Células Escamosas
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Adenocarcinoma
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Protocolos de Quimioterapia Combinada Antineoplásica
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article