Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript.
Science
; 287(5457): 1500-3, 2000 Feb 25.
Article
em En
| MEDLINE
| ID: mdl-10688801
ABSTRACT
Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT(-) virus but not with LAT(+) viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ceratite Herpética
/
Apoptose
/
Latência Viral
/
Herpesvirus Humano 1
/
Neurônios
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article