Tityustoxin effect on nerve compound action potentials requires extracellular sodium.
Neurosci Lett
; 282(1-2): 25-8, 2000 Mar 17.
Article
em En
| MEDLINE
| ID: mdl-10715073
ABSTRACT
Previous studies have demonstrated that Li(+) ions can substitute for Na(+) in a variety of functional systems. Using the single sucrose-gap recording technique, we measured the nerve compound action potential to study the effects of tityustoxin (an alpha-scorpion toxin that selectively inhibits fast Na(+) channel inactivation) upon removal of extracellular Na(+). Our results suggest that tityustoxin requires the presence of extracellular Na(+) to produce its typical pharmacological effect on Na(+) channel inactivation kinetics, but not to bind to its site.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nervo Isquiático
/
Venenos de Escorpião
/
Sódio
/
Espaço Extracelular
/
Neurotoxinas
Limite:
Animals
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article