Treatment of opioid-dependent pregnant women with buprenorphine.
Addiction
; 95(2): 239-44, 2000 Feb.
Article
em En
| MEDLINE
| ID: mdl-10723852
ABSTRACT
AIMS:
To assess the maternal and fetal acceptability of buprenorphine and neonatal abstinence syndrome (NAS) in children born to buprenorphine-maintained mothers. DESIGN ANDSETTING:
Open-label, flexible dosing, inpatient induction with outpatient maintenance, conducted at the University of Vienna within the existing pregnancy and drug addiction program.PARTICIPANTS:
Fifteen opioid-dependent pregnant women. INTERVENTION Sublingual buprenorphine tablets (1-10 mg/day). MEASUREMENTS Mothers withdrawal symptoms (Wang Scale), nicotine dependence (Fagerström Scale FTQ) and urinalysis. Neonates birth outcome and NAS (Finnegan Scale).FINDINGS:
All subjects were opioid-, nicotine- and cannabis-dependent. Buprenorphine was well tolerated during induction (Wang Score < or = 4) and illicit opioid use was negligible (91% opioid-negative). All maternal, fetal and neonatal safety laboratory measures were within normal limits or not of clinical significance. Mean birth outcome measures including gestational age at delivery (39.6 +/- 1.5 weeks), Apgar scores (1 min = 8.9; 5 min = 9.9; and 10 min = 10), birth weight (3049 +/- 346 g), length (49.8 +/- 1.9 cm) and head circumference (34.1 +/- 1.8 cm) were within normal limits. The NAS was absent, mild (without treatment) and moderate (with treatment) in eight, four and three neonates, respectively. The mean duration of NAS was 1.1 days.CONCLUSIONS:
Buprenorphine appears to be well accepted by mother and fetus, and associated with a low incidence of NAS. Further investigation of buprenorphine as a maintenance agent for opioid-dependent pregnant women is needed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações na Gravidez
/
Buprenorfina
/
Transtornos Relacionados ao Uso de Opioides
/
Entorpecentes
Limite:
Female
/
Humans
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Newborn
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Pregnancy
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article