Bioactive alkaloids from Brunsvigia radulosa.
Phytochemistry
; 53(5): 587-91, 2000 Mar.
Article
em En
| MEDLINE
| ID: mdl-10724185
A phytochemical investigation of the bulbs of Brunsvigia radulosa yielded the new alkaloid 1-O-acetylnorpluviine, together with the known structures 1-epideacetylbowdensine, crinamine, crinine, hamayne, lycorine, anhydrolycorin-6-one and sternbergine. All structures were established by spectroscopic evidence. Some of the 13C assignments which were reported for crinamine and hamayne were corrected by means of 2D NMR techniques. In order to provide a further structure for biological testing, crinamine was converted to apohaemanthamine. The alkaloids were tested for activity against two strains of cultured Plasmodium falciparum and for cytotoxicity with BL6 mouse melanoma cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Alcaloides de Amaryllidaceae
/
Alcaloides
/
Indolizinas
Limite:
Animals
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article