Differential activation of MAP kinase family members triggered by CD99 engagement.
FEBS Lett
; 470(3): 350-4, 2000 Mar 31.
Article
em En
| MEDLINE
| ID: mdl-10745095
ABSTRACT
The molecular basis for the modulatory properties of CD99 is not well understood. Treatment of human Jurkat T lymphocytes with anti-CD99 antibody led to activation of three mitogen-activated protein kinase (MAPK) members, ERK, JNK, and p38 MAPK, along with homotypic aggregation. While phosphorylation of ERK and JNK was inhibited by the pretreatment of a PKC inhibitor, bisindolylmaleimide I, activation of p38 MAPK was upregulated by the same pretreatment. The signaling pathways to MAPKs by CD99 engagement were independent of PI-3 kinase, distinguishing from those by CD3 engagement. Among MAPKs, ERK pathway was essential for homotypic aggregation together with intracytoplasmic Ca(2+).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Agregação de Receptores
/
Receptores de Hialuronatos
/
Proteínas Quinases Ativadas por Mitógeno
/
Sistema de Sinalização das MAP Quinases
Limite:
Humans
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article