Mice lacking the norepinephrine transporter are supersensitive to psychostimulants.
Nat Neurosci
; 3(5): 465-71, 2000 May.
Article
em En
| MEDLINE
| ID: mdl-10769386
ABSTRACT
The action of norepinephrine (NE) is terminated, in part, by its uptake into presynaptic noradrenergic neurons by the plasma-membrane NE transporter (NET), which is a target for antidepressants and psychostimulants. Disruption of the NET gene in mice prolonged the clearance of NE and elevated extracellular levels of this catecholamine. In a classical test for antidepressant drugs, the NET-deficient (NET-/-) animals behaved like antidepressant-treated wild-type mice. Mutants were hyper-responsive to locomotor stimulation by cocaine or amphetamine. These responses were accompanied by dopamine D2/D3 receptor supersensitivity. Thus altering NET expression significantly modulates midbrain dopaminergic function, an effect that may be an important component of the actions of antidepressants and psychostimulants.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Transporte
/
Deleção de Genes
/
Simportadores
/
Estimulantes do Sistema Nervoso Central
/
Antidepressivos
Limite:
Animals
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article