Functional regulation of tactile sense by brain-derived neurotrophic factor in adult rats during acute inflammation.
Neuroscience
; 97(1): 171-5, 2000.
Article
em En
| MEDLINE
| ID: mdl-10771348
ABSTRACT
Nerve growth factor is present in skin in limiting amounts and is known to regulate the plasticity and the sensitivity of nociceptive neurons. Recently, knock-out mouse studies showed that neurotrophin-3 and brain-derived neurotrophic factor are required for the postnatal survival and functional maturation, respectively, of tactile sensory neurons. However, the roles of neurotrophin-3 and brain-derived neurotrophic factor in adult sensory neurons have not been clarified. Here, we report an unexpected and marked acute loss of tactile sense in the rat hind paw after adjuvant-induced inflammation. This loss was shown to be closely correlated with decreases in the expression of brain-derived neurotrophic factor, and to a lesser extent of neurotrophin-3 in the inflamed skin. Administration of brain-derived neurotrophic factor, but not neurotrophin-3, after inflammation accelerated the recovery of tactile sense. These results suggested a role of brain-derived neurotrophic factor in the physiological regulation of tactile sense in adulthood.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tato
/
Fator Neurotrófico Derivado do Encéfalo
/
Inflamação
Limite:
Animals
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article