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Anti-ulcerogenic effects of Spartium junceum flowers on in vivo test models in rats.
Yesilada, E; Takaishi, Y; Fujita, T; Sezik, E.
Afiliação
  • Yesilada E; Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Hipodrom 06330, Ankara, Turkey. yesilada@tr-net.net.tr
J Ethnopharmacol ; 70(3): 219-26, 2000 Jun.
Article em En | MEDLINE | ID: mdl-10837986
Flowers of Spartium junceum L. (Fabaceae) are used for the treatment of gastric ulcers in Turkish folk medicine. Through bioassay-guided fractionation using chemical and chromatographical means and water immersion and restraint-induced stress ulcer model in rats, a saponin fraction was determined as the potent anti-ulcerogenic ingredient. The active fraction was also highly effective in preventing ethanol- and pyloric ligation-induced gastric lesions as well as inhibiting gastric secretion volume, gastric pH and titratable acidity, but did not affect the hexosamine content of the gastric mucosa. A novel oleanen-type triterpenic saponin, named as spartitrioside, was isolated as the active principle by using chromatographical separation techniques.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plantas Medicinais / Úlcera Gástrica / Antiulcerosos Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals País/Região como assunto: Asia Idioma: En Ano de publicação: 2000 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plantas Medicinais / Úlcera Gástrica / Antiulcerosos Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals País/Região como assunto: Asia Idioma: En Ano de publicação: 2000 Tipo de documento: Article