Epoxy-acetogenins and other polyketide epoxy derivatives as inhibitors of the mitochondrial respiratory chain complex I.
Planta Med
; 66(4): 318-23, 2000 May.
Article
em En
| MEDLINE
| ID: mdl-10865446
ABSTRACT
Annonaceous acetogenins (ACG), an extensive group of cytotoxic natural products, are antitumor agents whose main mode of action is inhibition of the mammalian mitochondrial complex I. Herein we describe the importance of the different chemical groups along the alkyl chain for optimal inhibitory potency, discussing the structurally relevant factors present in these compounds. For this purpose, a series of epoxide derivatives from alpha-linolenic acid were prepared and their activity compared with that of epoxy-acetogenins and tetrahydrofuranic (THF) acetogenins isolated from Rollinia membranacea.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Epóxi
/
Furanos
/
Lactonas
/
Mitocôndrias
/
NADH NADPH Oxirredutases
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article