Pharmacokinetics and penetration of danofloxacin into the gastrointestinal tract in healthy and in Salmonella typhimurium infected pigs.
Res Vet Sci
; 68(3): 211-6, 2000 Jun.
Article
em En
| MEDLINE
| ID: mdl-10877965
ABSTRACT
The pharmacokinetics and penetration of danofloxacin into the gastrointestinal tract in healthy pigs and in pigs experimentally infected with Salmonella typhimurium were studied. In the infected pigs, a decrease in body clearance and an increase in mean elimination half-life was observed (P < 0.01). Moreover a significant reduction in the volume of the peripheral compartment was found. Danofloxacin distributed well to the gastrointestinal tract achieving high AUC / AUC(plasma)ratios in both groups of pigs. However, compared to the healthy pigs AUC / AUC(plasma)ratios decreased in the infected pigs. Salmonella infection led to an increase in mean residence time (MRT) in the small intestines and lymph nodes and a decrease in MRT in caecum and colon.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Salmonelose Animal
/
Salmonella typhimurium
/
Suínos
/
Doenças dos Suínos
/
Fluoroquinolonas
/
Sistema Digestório
/
Anti-Infecciosos
Limite:
Animals
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article