[Peripheral blood stem cell collection in pediatric oncohematology. Experience with patients weighing less than 15 kg]. / Raccolta di cellule staminali periferiche in oncoematologia pediatrica. Esperienza su soggetti di peso inferiore a 15 kg.
Minerva Pediatr
; 52(3): 129-35, 2000 Mar.
Article
em It
| MEDLINE
| ID: mdl-10879003
ABSTRACT
BACKGROUND:
Leukapheresis for peripheral blood stem cell collection is increasingly being carried out in pediatric cancer patients. Aim of this study was to report experience of the Padua Apheresis Unit on a series of children weighting < 15 kg who have undergone such an apheresis procedure.METHODS:
This retrospective study includes 15 pediatric patients affected with various malignancies (neuroblastoma 7; acute myelogenous leukemia 3; rhabdomyosarcoma 2; PNET 1; retinoblastoma 1; Burkitt's lymphoma 1) collecting peripheral blood stem cells by a Cobe Spectra blood cell separator. Main procedure parameters, including vascular access, leukapheresis duration, blood flow rate, processed blood volumes, side effects, mononuclear and CD34+ cell yields, have been registered.RESULTS:
Altogether 22 sessions have been carried out, by processing a mean of 2.8 blood volumes. No leukapheresis related complications have been recorded, such as hypotension, hypocalcemia and hypothermia. Noteworthy, in 4 procedures two or more peripheral venipunctures have been performed to ensure an adequate blood flow.CONCLUSIONS:
Leukapheresis for peripheral blood stem cell collection can be safely and efficaciously carried out in pediatric patients, even weighing < 15 kg, on the condition that certain aspects of apheresis practice in children (vascular access, volume shifts, anticoagulation, side effects) are carefully considered.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Neoplásicas
/
Peso Corporal
/
Leucaférese
/
Neoplasias
Tipo de estudo:
Observational_studies
Limite:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
It
Ano de publicação:
2000
Tipo de documento:
Article