Fas/FADD-mediated activation of a specific program of inflammatory gene expression in vascular smooth muscle cells.
Nat Med
; 6(7): 790-6, 2000 Jul.
Article
em En
| MEDLINE
| ID: mdl-10888928
ABSTRACT
Apoptosis of smooth muscle cells is a common feature of vascular lesions but its pathophysiological significance is not known. We demonstrate that signals initiated by regulated Fas-associated death domain protein overexpression in rat vascular smooth muscle cells in the carotid artery induce expression of monocyte-chemoattractant protein-1 and interleukin-8, and cause massive immigration of macrophages in vivo. These chemokines, and a specific set of other pro-inflammatory genes, are also upregulated in human vascular smooth muscle cells during Fas-induced apoptosis, in part through a process that requires interleukin-1alpha activation. Induction of a pro-inflammatory program by apoptotic vascular smooth muscle cells may thus contribute to the pathogenesis of vascular disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Transporte
/
Apoptose
/
Receptor fas
/
Proteínas Adaptadoras de Transdução de Sinal
/
Inflamação
/
Músculo Liso Vascular
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article