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A European multicenter association study of HTR2A receptor polymorphism in bipolar affective disorder.
Massat, I; Souery, D; Lipp, O; Blairy, S; Papadimitriou, G; Dikeos, D; Ackenheil, M; Fuchshuber, S; Hilger, C; Kaneva, R; Milanova, V; Verheyen, G; Raeymaekers, P; Staner, L; Oruc, L; Jakovljevic, M; Serretti, A; Macciardi, F; Van Broeckhoven, C; Mendlewicz, J.
Afiliação
  • Massat I; Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Brussels, Belgium. imassat@ulb.ac.be
Am J Med Genet ; 96(2): 136-40, 2000 Apr 03.
Article em En | MEDLINE | ID: mdl-10893484
The available data on the role of 5-HT in a variety of behaviors support the hypothesis that a dysfunction in brain serotoninergic system activity contributes to vulnerability to major depression. The diversity in the electrophysiological actions of 5-HT in the central nervous system can now be categorized according to receptor subtypes and their respective effector mechanisms. In particular, the implication of central postsynaptic 5-HT2A receptor in affective disorders has been supported by findings consistent with the hypothesis of 5-HT2A receptor up-regulation in depression. For these reasons, the 5-HT2A receptor (HTR2A) gene can be considered as a candidate gene in bipolar affective disorder (BPAD). We tested the possible genetic contribution of the polymorphic DNA variation T102C in exon 1 of HTR2A (chromosome 13q14-21) gene in a large European multicentric case-control sample. Allele and genotype frequencies, as well as homo-heterozygote distributions were compared between the two groups of 309 bipolar affective disorder patients and 309 matched controls. No significant differences were observed in the allelic and genotypic (also for homo-heterozygote) distribution between BPAD and controls. These results indicate that, in our sample, the 5-HT2A receptor polymorphism studied is unlikely to play a major role in the genetic susceptibility to BPAD. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:136-140, 2000.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Transtorno Bipolar / Receptores de Serotonina Tipo de estudo: Clinical_trials / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Ano de publicação: 2000 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Transtorno Bipolar / Receptores de Serotonina Tipo de estudo: Clinical_trials / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Ano de publicação: 2000 Tipo de documento: Article