[Inhibition of renal carbonic anhydrase as a respiratory stimulant-- an obsolete indication?]. / Hemmung der renalen Carboanhydrase als Atemstimulans--eine obsolete Indikation?
Ther Umsch
; 57(6): 351-4, 2000 Jun.
Article
em De
| MEDLINE
| ID: mdl-10894018
ABSTRACT
Inhibition of carbonic anhydrase in general or specific inhibition of one the different isoenzymes results in a significant metabolic acidosis due to renal bicarbonate loss. The increase of arterial pCO2 stimulates central and peripheral chemoreceptors and enhances ventilation. The inhibition of carbonic anhydrase as a respiratory stimulant is an accepted measure for the prevention of acute mountain sickness, has been used for a restricted number of subjects with sleep-disordered breathing or chronic hypoxaemic lung disease. The few indications and the narrow therapeutic index restrict the use of carbonic anhydrase blockers as stimulants for ventilation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenômenos Fisiológicos Respiratórios
/
Inibidores da Anidrase Carbônica
Limite:
Humans
Idioma:
De
Ano de publicação:
2000
Tipo de documento:
Article