Preparation and antimicrobial activity of micacocidin.
J Antibiot (Tokyo)
; 53(5): 532-9, 2000 May.
Article
em En
| MEDLINE
| ID: mdl-10908118
ABSTRACT
Micacocidin (3), a Zn-free derivative of micacocidin A (1), was prepared to evaluate its antimicrobial activity in comparison with 1 and to obtain a starting material for chemical modification of 1. The structure of 3, quite unlike those of any previously known antimicrobial agents, was elucidated by 1-D and 2-D homonuclear and heteronuclear NMR and mass spectroscopy. Micacocidin (3) thus prepared exhibited weak or no antibacterial activity except against Mycoplasma species, i.e. 3 showed stronger activity than 1. It is noteworthy that 3 displayed high activity against fungi such as Candida, Aspergillus and Trichophyton species.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Bactérias
/
Fungos
/
Antibacterianos
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article