Aldose reductase-deficient mice develop nephrogenic diabetes insipidus.
Mol Cell Biol
; 20(16): 5840-6, 2000 Aug.
Article
em En
| MEDLINE
| ID: mdl-10913167
ABSTRACT
Aldose reductase (ALR2) is thought to be involved in the pathogenesis of various diseases associated with diabetes mellitus, such as cataract, retinopathy, neuropathy, and nephropathy. However, its physiological functions are not well understood. We developed mice deficient in this enzyme and found that they had no apparent developmental or reproductive abnormality except that they drank and urinated significantly more than their wild-type littermates. These ALR2-deficient mice exhibited a partially defective urine-concentrating ability, having a phenotype resembling that of nephrogenic diabetes insipidus.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aldeído Redutase
/
Camundongos Knockout
/
Diabetes Insípido Nefrogênico
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article