Prognostic significance of matrix metalloproteinases 2 and 9 in bladder cancer.
Anticancer Res
; 20(3B): 2009-13, 2000.
Article
em En
| MEDLINE
| ID: mdl-10928143
ABSTRACT
BACKGROUND:
The levels of matrix metalloproteinases MMP-2 and MMP-9 (type IV collagenases), which degrade the extracellular matrix of the basement membrane, were evaluated as prognostic indicators of metastasis in urothelial carcinoma. MATERIALS ANDMETHODS:
Quantitative gel zymography and immunohistochemistry were used and compared with clinical data at the follow-up period of 36 months.RESULTS:
Zymographical analysis of the levels of MMP-9 and active MMP-2 showed a statistically significant increase with tumor grade and invasiveness. This correlation was confirmed by immunohistochemical analysis of MMP-9 expression. However, the correlation between the levels of both gelatinases with recurrence in superficial tumours or progression in invasive tumours was not statistically significant.CONCLUSION:
MMPs may have an important role in the invasion mechanism of urothelial cancer and could be useful prognostic markers for patients with bladder carcinoma. The relationship between MMP-2 and MMP-9 expression and the metastatic potential of bladder carcinoma needs further evaluation in subsequent clinical studies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Bexiga Urinária
/
Carcinoma de Células de Transição
/
Biomarcadores Tumorais
/
Metaloproteinase 2 da Matriz
/
Metaloproteinase 9 da Matriz
/
Proteínas de Neoplasias
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article