Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.
Science
; 289(5482): 1159-64, 2000 Aug 18.
Article
em En
| MEDLINE
| ID: mdl-10947977
ABSTRACT
TR3, an immediate-early response gene and an orphan member of the steroid-thyroid hormone-retinoid receptor superfamily of transcription factors, regulates apoptosis through an unknown mechanism. In response to apoptotic stimuli, TR3 translocates from the nucleus to mitochondria to induce cytochrome c release and apoptosis. Mitochondrial targeting of TR3, but not its DNA binding and transactivation, is essential for its proapoptotic effect. Our results reveal a mechanism by which a nuclear transcription factor translocates to mitochondria to initiate apoptosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Apoptose
/
Grupo dos Citocromos c
/
Proteínas de Ligação a DNA
/
Mitocôndrias
Limite:
Humans
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article