Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers.
Science
; 289(5484): 1524-9, 2000 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-10968783
ABSTRACT
Several nuclear hormone receptors involved in lipid metabolism form obligate heterodimers with retinoid X receptors (RXRs) and are activated by RXR agonists such as rexinoids. Animals treated with rexinoids exhibited marked changes in cholesterol balance, including inhibition of cholesterol absorption and repressed bile acid synthesis. Studies with receptor-selective agonists revealed that oxysterol receptors (LXRs) and the bile acid receptor (FXR) are the RXR heterodimeric partners that mediate these effects by regulating expression of the reverse cholesterol transporter, ABC1, and the rate-limiting enzyme of bile acid synthesis, CYP7A1, respectively. Thus, these RXR heterodimers serve as key regulators of cholesterol homeostasis by governing reverse cholesterol transport from peripheral tissues, bile acid synthesis in liver, and cholesterol absorption in intestine.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Glicoproteínas
/
Colesterol
/
Receptores do Ácido Retinoico
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Receptores Citoplasmáticos e Nucleares
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Transportadores de Cassetes de Ligação de ATP
/
Absorção Intestinal
/
Intestino Delgado
/
Fígado
Limite:
Animals
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article