Synthesis of 2-fluoro-6-O-propargyl-11,12-carbamate ketolides. A novel class of antibiotics.
Org Lett
; 2(19): 2951-4, 2000 Sep 21.
Article
em En
| MEDLINE
| ID: mdl-10986080
ABSTRACT
A novel class of 2-fluoro-6-O-propargyl-11,12-carbamate ketolide derivatives of erythromycin has been synthesized for antibacterial SAR studies. Replacement of the C2-hydrogen by a fluorine atom allows the synthesis of 6-O-propargylic ketones and electron-deficient 6-O-propargylic aromatic derivatives by preventing intramolecular C2-enolate Michael cyclization.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Eritromicina
/
Antibacterianos
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article