Oxythiamine hexafluorophosphate monohydrate, a thiamine antagonist with the same conformation as thiamine.
Acta Crystallogr C
; 56 ( Pt 10): 1284-6, 2000 Oct.
Article
em En
| MEDLINE
| ID: mdl-11025328
ABSTRACT
In the title compound, 3-[(3,4-dihydro-2-methyl-4-oxopyrimidin-5-yl) methyl]-5-(2-hydroxyethyl)-4-methylthiazolium hexafluorophosphate monohydrate,C(12)H(16)N(3)O(2)S(+).PF(6)(-).H(2)O, oxythiamine is a monovalent cation with a neutral oxopyrimidine ring. The molecule assumes the F conformation, which is a common form for thiamine but which is substantially different from the unusual V conformation found in the chloride and hydrochloride salts of oxythiamine. The anion-bridging interaction, C-H...anion...pyrimidine, is emphasized as being important for stabilization of the F conformation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxitiamina
/
Tiamina
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article