HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia.
Am J Clin Nutr
; 72(5): 1095-100, 2000 Nov.
Article
em En
| MEDLINE
| ID: mdl-11063434
ABSTRACT
BACKGROUND:
Orange juice-a rich source of vitamin C, folate, and flavonoids such as hesperidin-induces hypocholesterolemic responses in animals.OBJECTIVE:
We determined whether orange juice beneficially altered blood lipids in subjects with moderate hypercholesterolemia.DESIGN:
The sample consisted of 16 healthy men and 9 healthy women with elevated plasma total and LDL-cholesterol and normal plasma triacylglycerol concentrations. Participants incorporated 1, 2, or 3 cups (250 mL each) of orange juice sequentially into their diets, each dose over a period of 4 wk. This was followed by a 5-wk washout period. Plasma lipid, folate, homocyst(e)ine, and vitamin C (a compliance marker) concentrations were measured at baseline, after each treatment, and after the washout period.RESULTS:
Consumption of 750 mL but not of 250 or 500 mL orange juice daily increased HDL-cholesterol concentrations by 21% (P < 0.001), triacylglycerol concentrations by 30% (from 1.56 +/- 0.72 to 2.03 +/- 0.91 mmol/L; P < 0.02), and folate concentrations by 18% (P < 0.01); decreased the LDL-HDL cholesterol ratio by 16% (P < 0.005); and did not affect homocyst(e)ine concentrations. Plasma vitamin C concentrations increased significantly during each dietary period (2.1, 3.1, and 3.8 times, respectively).CONCLUSIONS:
Orange juice (750 mL/d) improved blood lipid profiles in hypercholesterolemic subjects, confirming recommendations to consume >/=5-10 servings of fruit and vegetables daily.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bebidas
/
Citrus
/
Hipercolesterolemia
/
HDL-Colesterol
Tipo de estudo:
Guideline
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article