Transcutaneous immunization: a human vaccine delivery strategy using a patch.
Nat Med
; 6(12): 1403-6, 2000 Dec.
Article
em En
| MEDLINE
| ID: mdl-11100128
ABSTRACT
Transcutaneous immunization, a topical vaccine application, combines the advantages of needle-free delivery while targeting the immunologically rich milieu of the skin. In animal studies, this simple technique induces robust systemic and mucosal antibodies against vaccine antigens. Here, we demonstrate safe application of a patch containing heat-labile enterotoxin (LT, derived from Escherichia coli) to humans, resulting in robust LT-antibody responses. These findings indicate that TCI is feasible for human immunization, and suggest that TCI may enhance efficacy as well as improve vaccine delivery.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxinas Bacterianas
/
Vacinas Bacterianas
/
Vacinação
/
Proteínas de Escherichia coli
/
Enterotoxinas
Limite:
Humans
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article