In vitro and in vivo efficacies of T-3811ME (BMS-284756) against Mycoplasma pneumoniae.
Antimicrob Agents Chemother
; 45(1): 312-5, 2001 Jan.
Article
em En
| MEDLINE
| ID: mdl-11120986
ABSTRACT
T-3811, the free base of T-3811ME (BMS-284756), a new des-F(6)-quinolone, showed a potent in vitro activity (MIC at which 90% of the isolates tested are inhibited [MIC(90)], 0.0313 microg/ml) against Mycoplasma pneumoniae. The MIC(90) of T-3811 was 4-fold higher than that of clarithromycin but was 4- to 8-fold lower than those of trovafloxacin, gatifloxacin, gemifloxacin, and moxifloxacin and was 16- to 32-fold lower than those of levofloxacin, ciprofloxacin, and minocycline. In an experimental M. pneumoniae pneumonia model in hamsters, after the administration of T-3811ME (20 mg/kg of body weight as T-3811, once daily, orally) for 5 days, the reduction of viable cells of M. pneumoniae in bronchoalveolar lavage fluid was greater than those of trovafloxacin, levofloxacin, and clarithromycin (20 and 40 mg/kg, orally) (P < 0.05).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pneumonia por Mycoplasma
/
Quinolonas
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Indóis
/
Anti-Infecciosos
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Mycoplasma pneumoniae
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article