The role of PPAR-gamma in macrophage differentiation and cholesterol uptake.
Nat Med
; 7(1): 41-7, 2001 Jan.
Article
em En
| MEDLINE
| ID: mdl-11135614
ABSTRACT
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), the transcription factor target of the anti-diabetic thiazolidinedione (TZD) drugs, is reported to mediate macrophage differentiation and inflammatory responses. Using PPAR-gamma-deficient stem cells, we demonstrate that PPAR-gamma is neither essential for myeloid development, nor for such mature macrophage functions as phagocytosis and inflammatory cytokine production. PPAR-gamma is required for basal expression of CD36, but not for expression of the other major scavenger receptor responsible for uptake of modified lipoproteins, SR-A. In wild-type macrophages, TZD treatment divergently regulated CD36 and class A macrophage-scavenger receptor expression and failed to induce significant cellular cholesterol accumulation, indicating that TZDs may not exacerbate macrophage foam-cell formation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Diferenciação Celular
/
Colesterol
/
Receptores Citoplasmáticos e Nucleares
/
Macrófagos
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article