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Mucosal leishmaniasis ("espundia") responsive to low dose of N-methyl glucamine (Glucantime) in Rio de Janeiro, Brazil.
Oliveira-Neto, M P; Mattos, M; Pirmez, C; Fernandes, O; Gonçalves-Costa, S C; Souza, C F; Grimaldi, G.
Afiliação
  • Oliveira-Neto MP; Hospital Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil. onetohec@fiocruz.br
Rev Inst Med Trop Sao Paulo ; 42(6): 321-5, 2000.
Article em En | MEDLINE | ID: mdl-11136518
ABSTRACT
Response to treatment with antimonial drugs varies considerably depending on the parasite strain involved, immune status of the patient and clinical form of the disease. Therapeutic regimens with this first line drug have been frequently modified both, in dose and duration of therapy. A regimen of 20 mg/kg/day of pentavalent antimony (Sb5+) during four weeks without an upper limit on the daily dose is currently recommended for mucosal disease ("espundia"). Side-effects with this dose are more marked in elderly patients, more commonly affected by this form of leishmaniasis. According to our experience, leishmaniasis in Rio de Janeiro responds well to antimony and, in cutaneous disease, high cure rates are obtained with 5 mg/kg/day of Sb5+ during 30 to 45-days. In this study a high rate of cure (91.4%) employing this dose was achieved in 36 patients with mild disease in this same geographic region. Side-effects were reduced and no antimony refractoriness was noted with subsequent use of larger dose in patients that failed to respond to initial schedule.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organometálicos / Leishmaniose Mucocutânea / Meglumina / Antiprotozoários Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Ano de publicação: 2000 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organometálicos / Leishmaniose Mucocutânea / Meglumina / Antiprotozoários Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies Limite: Female / Humans / Male / Middle aged País/Região como assunto: America do sul / Brasil Idioma: En Ano de publicação: 2000 Tipo de documento: Article