[A fragment of collagen XVIII inhibits angiogenesis]. / Et kollagen XVIII-fragment hemmer angiogenese.
Tidsskr Nor Laegeforen
; 120(29): 3547-50, 2000 Nov 30.
Article
em Nor
| MEDLINE
| ID: mdl-11188382
ABSTRACT
BACKGROUND:
Malignant tumours may produce substances with both stimulatory and inhibitory effect on angiogenesis. MATERIAL ANDMETHODS:
A protein fragment with angiogenesis-inhibiting potential was recently identified in conditioned media from a murine endothelial tumour cell line.RESULTS:
The angiogenesis inhibitor, endostatin, is a 20 kDa C-terminal fragment of collagen XVIII, a proteoglycan/collagen found in vessel walls and basement membranes. The generation of endostatin or endostatin-like collagen XVIII fragments is catalyzed by proteolytic enzymes, including cathepsin L and matrix metalloproteases, that cleave peptide bonds within the protease-sensitive hinge region of the C-terminal domain.INTERPRETATION:
The physiological processing of collagen XVIII to endostatin may represent a local control mechanism for the regulation of angiogenesis. The outcome of ongoing clinical trials will determine the role of endostatin as a possible angiogenesis-inhibiting drug in the future.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Colágeno
/
Inibidores da Angiogênese
/
Neoplasias
/
Neovascularização Patológica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
Nor
Ano de publicação:
2000
Tipo de documento:
Article