Topical permethrin exposure inhibits antibody production and macrophage function in C57Bl/6N mice.
Food Chem Toxicol
; 39(2): 133-9, 2001 Feb.
Article
em En
| MEDLINE
| ID: mdl-11267706
ABSTRACT
Permethrin was applied to the shaved dorsal interscapular region of C57Bl/6N mice at doses of 0.5, 1.5 or 5.0 microl/day. These doses corresponded to approximately 22-220 mg/kg/day topical insecticide. Mice were exposed to permethrin in this manner daily for 10 or 30 consecutive days, or every other day for 7 or 14 exposures. The splenic macrophage chemiluminescent response was depressed in a dose-dependent manner at 2 and 10 days post-exposure to permethrin. Phagocytic ability of macrophages was not inhibited. Antibody production as shown by plaque-forming cell (PFC) assay decreased significantly after 10 consecutive days of exposure to permethrin. These data indicate that topical permethrin exposure may produce systemic immune effects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piretrinas
/
Inseticidas
/
Macrófagos
/
Formação de Anticorpos
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article