Potent integrin antagonists from a small library of RGD-including cyclic pseudopeptides.
Org Lett
; 3(7): 1001-4, 2001 Apr 05.
Article
em En
| MEDLINE
| ID: mdl-11277780
ABSTRACT
[structure see text]. A small library of cyclic RGD pseudopentapeptides incorporating stereoisomeric 6,5- and 7,5-fused bicyclic lactams was synthesized with the aim of developing active and selective integrin antagonists. The solid-phase synthesis and activity of these RGD derivatives is described. The approach led to two of the most active known inhibitors of alpha(V)beta3 receptor.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Compostos Bicíclicos com Pontes
/
Receptores de Vitronectina
/
Lactamas
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article