Cellular aspects of folate and antifolate membrane transport.
Acta Biochim Pol
; 47(3): 735-49, 2000.
Article
em En
| MEDLINE
| ID: mdl-11310973
ABSTRACT
Folates--one carbon carriers--take part in the metabolism of purine, thymidylate and some amino acids. Internalization of these compounds employs several mechanisms of transport systems. Reduced folate carriers and folate receptors play the most important role in this process. The physiological role of these molecules in normal and neoplastic cells is described regarding changes in transport activity and connection of transport systems with resistance to antifolates and cancer development.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Membrana Celular
/
Receptores de Superfície Celular
/
Ácido Fólico
/
Antagonistas do Ácido Fólico
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article