[Infections caused by Stenotrophomonas maltophilia (SMA) in intensive care patients--a prospective case-control study]. / Infektionen durch Stenotrophomonas maltophilia (SMA) bei Intensivpatienten--eine prospektive Fall-Kontrollstudie.
Dtsch Med Wochenschr
; 126(18): 514-8, 2001 May 04.
Article
em De
| MEDLINE
| ID: mdl-11381633
ABSTRACT
BACKGROUND AND OBJECTIVE:
The importance of Stenotrophomonas maltophilia (SMA) as an etiologic frequently polyresistant pathogen in severe nosocomial infections has increased.METHODS:
In our prospective study we evaluated the risk factors of nosocomial infections by SMA in our internal intensive care unit (ICU) over a one year period from July 1997 to June 1998.RESULTS:
111 patients (80 men, 31 women, mean age +/- SD 58.0 +/- 13.3 years) were treated for more than 5 days in the ICU. SMA were cultured in 16/111 patients (13 men, three women, mean age 57.8 +/- 3.4 years) out of bronchial secretions (68%), sputum (19%) and pleural fluid (13%). Univariate analysis resulted in 15 different risk factors (p < 0.05); however, multivariate analysis provided three independent risk factors chronic obstructive pulmonary disease (OR 95% CI [1.91; infinity]), length of stay in the ICU (OR 95% CI [1.07; 1.26]) and therapy with carbapenems before admittance to ICU (OR 95% CI [0.56; 153]). Four of 16 patients died due to an SMA-infection, two by purulent exacerbations of a chronic bronchitis and two by sepsis. Molecular typing of 18 SMA isolates in 15 patients resulted in 9 different genetic types and a clonal dissemination could only be confirmed in three patients.CONCLUSIONS:
In respiratory ICU SMA infections are favored by severe COPD, length of stay in the ICU and by selection pressure of applicated antibiotics, especially carbapenems.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Oportunistas
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Infecção Hospitalar
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Infecções por Bactérias Gram-Negativas
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Stenotrophomonas maltophilia
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
De
Ano de publicação:
2001
Tipo de documento:
Article