[Peri-osteocytic calcium fixation under calcitonin treatment. Microradiographic study using automatic analysis of images in 8 cases of osteogenesis imperfecta]. / Fixation calcique péri-ostéocytaire sous calcitonine. Etude microradiographique à l'analyseur automatique d'images dans huit cas d'ostéogénèse imparfaite

ABSTRACT

The authors treated eight cases of osteogenesis imperfecta using doses of 1 to 2 units of MRC over periods ranging from 6 weeks to 27 months. The lacunar surface area measured before and after treatment was greatly decreased as a result of the latter, probably as the result of marked calcium fixation around the osteocytes, though this effect seems to be transient. The hypothesis of an inactivation of calcitonin on a immunological basis or of a secondary hyperparathyroid reaction is suggested.