Lithium revisited.
Can J Psychiatry
; 46(4): 322-7, 2001 May.
Article
em En
| MEDLINE
| ID: mdl-11387787
ABSTRACT
OBJECTIVE:
To review lithium's utility in the treatment of mood disorders.METHOD:
We reviewed the safety, tolerability, teratogenicity, optimal dosing regimens, and mortality-lowering effects of lithium. Clinical relevance and scientific rigour determined which articles we selected for review.RESULTS:
Lithium is the paradigmatic treatment for bipolar disorder (BD). In treating BD, optimal maintenance plasma levels may be approximately 0.75 to 0.85 mEq/L. Although nephrogenic diabetes insipidus is not uncommon, irreversible renal failure due to lithium appears to be a rare, idiosyncratic event. Lithium-induced cardiovascular teratology appears to be less common than previously thought. Optimal lithium dosing may be once daily, this agent appears to bestow a robust suicide-lowering effect, and emerging data hint at neurotrophic and neuroprotective effects.CONCLUSION:
Lithium remains an effective and integral agent in the treatment of BD. Its ability to lower suicide rates in persons with BD warrants clinical attention.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtorno Bipolar
/
Compostos de Lítio
Limite:
Humans
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article