Neuregulin and ErbB receptor signaling pathways in the nervous system.
Curr Opin Neurobiol
; 11(3): 287-96, 2001 Jun.
Article
em En
| MEDLINE
| ID: mdl-11399426
ABSTRACT
The neuregulins are a complex family of factors that perform many functions during neural development. Recent experiments have shown that neuregulins promote neuronal migration and differentiation, and regulate the selective expression of neurotransmitter receptors in neurons and at the neuromuscular junction. They also regulate glial commitment, proliferation, survival and differentiation. At interneuronal synapses, neuregulin ErbB receptors associate with PDZ-domain proteins at postsynaptic densities where they can modulate synaptic plasticity. How this combinatorial network - comprising many neuregulin ligands that signal through distinct combinations of dimeric ErbB receptors - elicits its multitude of biological effects is beginning to be resolved.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neurregulinas
/
Receptores ErbB
/
Proteínas do Tecido Nervoso
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article