Chemopreventive activity of isoquinoline alkaloids from Corydalis plants.
Planta Med
; 67(5): 473-5, 2001 Jul.
Article
em En
| MEDLINE
| ID: mdl-11488467
ABSTRACT
Eighteen isoquinoline alkaloids including protoberberines (1-12), benzophenanthridines (13-16) and an aporphine (17) isolated from plants of Corydalis species (Fumariaceae) were tested for inhibitory effects on Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol 13-acetate in Raji cells. In a primary screening test, all of the isoquinoline alkaloids showed inhibitory activity with the IC50 values being in the range of 140-410 mol ratio/32 pmol TPA. The data demonstrate that these isoquinoline alkaloids might be valuable as anti-tumor promoters.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Papaver
/
Aporfinas
/
Plantas Medicinais
/
Herpesvirus Humano 4
/
Alcaloides
/
Isoquinolinas
/
Antineoplásicos Fitogênicos
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article