LLU-alpha, an endogenous metabolite of gamma-tocopherol, is more effective against metal nephrotoxicity in rats than gamma-tocopherol.
Toxicol Lett
; 122(3): 255-65, 2001 Jul 06.
Article
em En
| MEDLINE
| ID: mdl-11489360
ABSTRACT
Antioxidants of the vitamin E family have protective effects against metal toxicity. We examined the protective effect of racemic LLU-alpha [2,7,8-trimethyl-2-(carboxyethyl)-6-hydroxychroman] a metabolite of gamma-tocopherol, in comparison to the effect of alpha- and gamma-tocopherol in rats treated with sodium dichromate (Cr) or thallium sulfate (Tl). We measured metal nephrotoxicity based on urinary protein excretion and discussed it with respect to the metal concentration in renal tissue. The ranking of antioxidant activity (iron stimulated lipid peroxidation, luminol and lucigenin amplified chemiluminescence) was determined in the following order alpha-tocopherol<gamma-tocopherol
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propionatos
/
Vitamina E
/
Cromanos
/
Rim
/
Metais
/
Antioxidantes
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article