Immunogenetics and clinical aspects of Takayasu's arteritis patients in a Mexican Mestizo population.
Clin Exp Rheumatol
; 19(4): 439-43, 2001.
Article
em En
| MEDLINE
| ID: mdl-11491500
ABSTRACT
OBJECTIVE:
The aim of the present work was to study the association between HLA alleles and Takayasu's arteritis in Mexican Mestizo patients.METHODS:
The study included 26 Mexican Mestizo patients with Takayasu's arteritis and 99 healthy unrelated individuals. HLA-A, -B and -DR alleles were determined by polymerase chain reaction PCR-SSPRESULTS:
Increased gene frequencies were demonstrated for HLA-B15(p=0.009,pC=0.020,OR=3.24,EF=11.9%) and HLA-B52 (p=0.008, pC=0.027, OR=5.16, EF=7.7%), and a decreased frequency for the HLA-A24 allele in patients compared to normal controls (p=0.035, pC=NS, PF=11.1%). When HLA typing was correlated to clinicalfeatures in 24 cases, wefound an increasedfrequencies of HLA-DR14 in patients with systemic arterial hypertension (p=0.005, pC=0.004, OR=24.6, EF=38.3%) and HLA-A2 on patients with pulmonary involvement (p=0.034, pC=0.036, OR=3.67, EF=40.4%) when compared to patients without these clinical manifestations.CONCLUSION:
These data confirm HLA-B52 as a relevant susceptibility allele for Takayasu's arteritis and suggest that HLA-B15 could be important as a marker of the disease in Mexican patients. Other class I and/or class II alleles could also be relevant as markers for the clinical features present in these patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Indígenas Norte-Americanos
/
Arterite de Takayasu
/
Antígenos HLA
Tipo de estudo:
Etiology_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Mexico
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article