beta amyloid-induced disruption of ionic balance: studies on the isolated frog labyrinth.
Neuroreport
; 12(11): 2493-7, 2001 Aug 08.
Article
em En
| MEDLINE
| ID: mdl-11496136
The beta-amyloid peptide (A beta) is a key player in the pathogenesis of Alzheimer's disease. Although its mechanisms of action are not fully elucidated, a disruption of ionic homeostasis has been suggested, and A beta aggregation in fibrils seems correlated to its toxic potential. In the present work, we studied the effects of different A beta fragments on the activity of frog ampullar nerve fibers. Our results show that A beta fragments are able to reduce ampullar nerve responses, with a potency correlated to their fibrillogenic capability. This study may have clinical implications, since vestibular problems are often reported in Alzheimer patients, and provide a model for the dissection of A beta effects in a simple multicomponent system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Equilíbrio Hidroeletrolítico
/
Canais Semicirculares
/
Vestíbulo do Labirinto
/
Peptídeos beta-Amiloides
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article