Acute left ventricular failure following melphalan and fludarabine conditioning.
Bone Marrow Transplant
; 28(1): 101-3, 2001 Jul.
Article
em En
| MEDLINE
| ID: mdl-11498753
ABSTRACT
Cardiotoxicity has rarely been reported as a complication of melphalan or fludarabine administration as single agents. Recently, melphalan and fludarabine have been used in combination as non-myeloablative conditioning chemotherapy prior to allogeneic stem cell transplantation. We have observed the development of severe left ventricular failure in three of 21 patients treated with this combination. Cardiotoxicity in this context has not previously been reported and has implications for the assessment, monitoring and treatment of patients undergoing pre-transplant conditioning with melphalan and fludarabine.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vidarabina
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Disfunção Ventricular Esquerda
/
Condicionamento Pré-Transplante
/
Melfalan
Tipo de estudo:
Etiology_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article