Rapid development and plasticity of layer 2/3 maps in rat barrel cortex in vivo.
Neuron
; 31(2): 305-15, 2001 Aug 02.
Article
em En
| MEDLINE
| ID: mdl-11502260
ABSTRACT
Cortical synaptic circuitry develops rapidly in the second postnatal week, simultaneous with experience-dependent turnover of dendritic spines. To relate the emergence of sensory maps to synaptogenesis, we recorded synaptic potentials evoked by whisker deflection in layer 2/3 neurons from postnatal day (P) 12 to 20. At P12, synaptic responses were undetectable. Only 2 days later in life (P14), receptive fields had mature organization. Sensory deprivation, if initiated before P14, disrupted receptive field structure. In layer 4, responses and maps were already mature by P12 and insensitive to deprivation, implying that barrel cortex develops from layer 4 to layer 2/3. Thus, P12-14 is a critical period shared by layer 2/3 synapses and their spines, suggesting that spine plasticity is involved in the refinement of maps.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Somatossensorial
/
Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article