3-Arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones as anti-inflammatory and analgesic agents.
Bioorg Med Chem
; 9(8): 2149-53, 2001 Aug.
Article
em En
| MEDLINE
| ID: mdl-11504651
ABSTRACT
Two series of 3-arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones 2 with potential anti-inflammatory and analgesic activity were prepared and tested. Pharmacological results revealed that all the title compounds, endowed with an arylsulphonyl side chain, possess good antalgic activity and fair anti-inflammatory properties. The analgesic profile of the two series, evaluated by the acetic acid writhing test, showed that compounds 2c, 2f and 2h, in particular, were the most active. Structure-activity relationships are briefly discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Enxofre
/
Tiazóis
/
Analgésicos
/
Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article